For painter Georgia O’Keeffe, it was love at first sight—and the beauty of Santa Fe still inspires many artists to call it home. Today, the New Mexico state capital boasts so many galleries, it’s the third-largest art market in the country, after New York City and Los Angeles—which is astounding for a population of just under 70,000. Beautifully preserved architecture from the city’s 400-year history lines its streets. Trendy shops delight visitors who flock to events such as the Santa Fe Opera season, chamber music and film festivals. And O’Keeffe’s beloved rugged desert landscape is a natural playground for adventurers, who can choose fly fishing, hiking, whitewater rafting, exploring rich Native American culture and more. No wonder readers of Condé Nast Traveler consistently rank Santa Fe among their favourite cities to visit.